Toxin database
A key project deliverable from the team at University of Liège was the construction of a publicly available annotated toxin database, containing analysis of nine African snake venoms.
By combining classical trypsin digestion with the advanced Multi-Enzymatic Limited Digestion (MELD) strategy, the Liège team enhanced venom protein identification and toxin quantification, paving the way for more targeted and effective antivenom development.
The database includes proteotranscriptomic data; post-translational modification; and relative quantification for nine snakes:
- Dendroaspis polylepis
- Echis ocellatus
- Echis leucogaster
- Echis coloratus
- Echis pyramidum leakeyi
- Dendroaspis viridis
- Dendroaspis angusticeps
- Dendroaspis jamesonii jamesonii
- Dendroaspis jamesonii kaimosae
Using the database
The database includes an index page.
Each page is easily accessible from this index, by using the appropriated link, and also displays a link to come back to the index page.
On the index page, a research tool has been created to allow a search for any information you may want, such as a sequence homology, an epitope, or a particular accession number.
From the index page, other options have also been added, such as information concerning the bioactivities of each toxin family, or the parameters used to acquire the data present in the database.
Article in 'Toxins'
More information about this research and the database can be found in the paper:
Dual proteomics strategies to dissect and quantify the components of nine medically important African snake venoms
Damien Redureau, Fernanda Gobbi Amorim, Thomas Crasset, Imre Berger, Christiane Schaffitzel, Stefanie Kate Menzies, Nicholas R. Casewell, Loïc Quinton
Toxins (2025), 17(5), 243
