ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordabillity
About Addvenom
Snakebites can be life-threatening when venom toxins are injected and enter the bloodstream. In areas where immediate access to specialised medical care is limited, bites by venomous snakes cause many thousands of deaths each year.
The EU-funded ADDovenom Project will use an innovative platform enabling generation of new snakebite treatment, based on a new disruptive protein-based nanoscaffold called ADDomer© – a megadalton- sized, thermostable synthetic virus-like particle with 60 high-affinity binding sites to neutralise and eliminate venom toxins from the bloodstream.
ADDovenom combines pioneering proteomics, transcriptomics and bioinformatics focusing on snake toxins provoking the most challenging syndromes like haemorrhage and paralysis. The aim is to develop first-in-class neutralising superbinders for snakebite therapy of unprecedented efficacy against the most prevalent Sub-Saharan snakes.
ADDomer©: Synthetic multiepitope display scaffold for next generation vaccines.
Research
The project comprises several technological challenges (rational design of new antigens as consensus toxins/epitope strings, design of an ADDobody library) and high-risk research (in vitro selection of new binders from a novel protein scaffold).
Latest news
ADDovenom annual meeting takes place in Portugal
Researchers from met last week for the fourth and final annual meeting of the ADDovenom project. Participating institutions University of Bristol Liverpool School of Tropical Medicine University of...
ADDovenom researchers give presentations at Venoms & Toxins 2024
Dr Stef Menzies and Iara Cardoso (Liverpool School of Tropical Medicine) attended the 11th International Toxinology Meeting: Venoms and Toxins in Oxford (20-22 August 2024), sharing results from the...
ADDovenom researchers publish preprint on echis venoms
A preprint paper providing a preclinical evaluation of the paraspecific efficacy of three Echis monospecific antivenoms has been published by Preprints with The Lancet. Co-authored by LSTM's...
ADDovenom features in Horizon magazine
Horizon, the EU Research and Innovation Magazine, has published an article about the ADDovenom project, and the search for more effective treatments for snakebites. It includes contributions from...
Konrad Hus awarded Marie Skłodowska Curie Fellowship
Dr Konrad Hus, a Research Associate at the University of Bristol, has been awarded a Marie Skłodowska Curie Fellowship for a project aimed at finding effective solutions for neutralizing the...
ADDovenom researchers lead Engineering Biology Mission Award project
ADDovenom researchers will lead a new project on snakebite treatments, one of twenty-two UKRI Engineering Biology Mission Awards announced by the UK government in February 2024. Prof Christiane...
New ADDobodies and ADDomers paper by ADDovenom researchers published
Four current and former researchers from the ADDovenom team at the University of Bristol are among the authors of a paper about ADDobodies and ADDomers, published in the journal Structure in January...
Thomas Crasset awarded FRIA doctoral scholarship
Congratulations to Thomas Crasset, who has been awarded a four-year FRIA (Fund for Research Training in Industry and Agriculture) doctoral scholarship by Le Fonds de la Recherche Scientifique...
ADDovenom project explained in new paper
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming, a paper describing the aims of the ADDovenom project and the methodologies being used, has...
Experts
ADDovenom synergistically combines unique expertise across a range of techniques and scientific disciplines, towards the objective to develop easy to produce, first-in-class neutralizing superbinders for snakebite therapy.