ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordabillity
About ADDovenom
Snakebites can be life-threatening when venom toxins are injected and enter the bloodstream. In areas where immediate access to specialised medical care is limited, bites by venomous snakes cause many thousands of deaths each year.
The EU-funded ADDovenom Project will use an innovative platform enabling generation of new snakebite treatment, based on a new disruptive protein-based nanoscaffold called ADDomer© – a megadalton- sized, thermostable synthetic virus-like particle with 60 high-affinity binding sites to neutralise and eliminate venom toxins from the bloodstream.
ADDovenom combines pioneering proteomics, transcriptomics and bioinformatics focusing on snake toxins provoking the most challenging syndromes like haemorrhage and paralysis. The aim is to develop first-in-class neutralising superbinders for snakebite therapy of unprecedented efficacy against the most prevalent Sub-Saharan snakes.
ADDomer©: Synthetic multiepitope display scaffold for next generation vaccines.
Research
The project comprises several technological challenges (rational design of new antigens as consensus toxins/epitope strings, design of an ADDobody library) and high-risk
research (in vitro selection of new binders from a novel protein scaffold).
Mass
spectrometry
and
bioinformatics
to analyse venoms
In vitro
evolution
and
characterization
of
ADDobody binders
Examination of neutralizing ability of selected ADDobodies
and gigabodies
Scalable bioprocess
for
gigabody production
bullets
Latest News
Snakebite antivenoms step into the future
ADDovenom researchers Nick Casewell and Robert Harrison, from Liverpool School of Tropical Medicine, have been interviewed for an article published by the Drug Discovery Network. Written by Stephanie DeMarco and published
Discussing venom with Radio 4’s Rutherford and Fry
Professor Nick Casewell, who leads the ADDovenom team at Liverpool School of Tropical Medicine (LSTM), has taken part in a venom-themed episode of The Curious Cases of Rutherford & Fry.
First ADDovenom annual meeting kicks off in Bristol
About the meeting (27 – 28th September 2021) : The ADDovenom partners gathered at the Harbour Hotel in Bristol for their first ever face-to-face meeting since the pandemic. Attendees journeyed
Research Associate Positions in Professor Berger-Schaffitzel lab
The role: We are seeking a post-doctoral research associate to perform laboratory-based snakebite envenoming (SBE) research in the Berger-Schaffitzel lab at the University of Bristol. The post-holder will use state-of-the-art
Abstract submission: Next-generation sequencing for venomics
ADDovenom researchers Fernanda Gobbi Amorim, Damien Redureau, Nicholas Casewell and Loïc Quinton have co-authored the following abstract, which has been submitted for the Venoms and Toxins 2021: The 8th International
ADDovenom / BBI webinar with Prof Gérard Lambeau
On 5 May 2021, ADDovenom teamed up with colleagues at the Bristol BioDesign Institute to organise a webinar with Professor Gérard Lambeau from CNRS (Centre national de la recherche scientifique).
Snakebite antivenoms step into the future
ADDovenom researchers Nick Casewell and Robert Harrison, from Liverpool School of Tropical Medicine, have been
Discussing venom with Radio 4’s Rutherford and Fry
Professor Nick Casewell, who leads the ADDovenom team at Liverpool School of Tropical Medicine (LSTM),
First ADDovenom annual meeting kicks off in Bristol
About the meeting (27 - 28th September 2021) :The ADDovenom partners gathered at the Harbour
Research Associate Positions in Professor Berger-Schaffitzel lab
The role:We are seeking a post-doctoral research associate to perform laboratory-based snakebite envenoming (SBE) research
Abstract submission: Next-generation sequencing for venomics
ADDovenom researchers Fernanda Gobbi Amorim, Damien Redureau, Nicholas Casewell and Loïc Quinton have co-authored the
ADDovenom / BBI webinar with Prof Gérard Lambeau
On 5 May 2021, ADDovenom teamed up with colleagues at the Bristol BioDesign Institute to
Experts
Christiane Berger-Schaffitzel
University of Bristol
~Project Coordinator~
Imre Berger
University of Bristol
Loïc Quinton
University of Liège
Renaud Vincentelli
Aix-Marseille University
Nicholas Casewell
Liverpool School of
Tropical Medicine
Robert Harrison
Liverpool School of
Tropical Medicine
Paula Alves
iBET
Antonio Roldão
iBET
