ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordabillity
About ADDovenom
Snakebites can be life-threatening when venom toxins are injected and enter the bloodstream. In areas where immediate access to specialised medical care is limited, bites by venomous snakes cause many thousands of deaths each year.
The EU-funded ADDovenom Project will use an innovative platform enabling generation of new snakebite treatment, based on a new disruptive protein-based nanoscaffold called ADDomer© – a megadalton- sized, thermostable synthetic virus-like particle with 60 high-affinity binding sites to neutralise and eliminate venom toxins from the bloodstream.
ADDovenom combines pioneering proteomics, transcriptomics and bioinformatics focusing on snake toxins provoking the most challenging syndromes like haemorrhage and paralysis. The aim is to develop first-in-class neutralising superbinders for snakebite therapy of unprecedented efficacy against the most prevalent Sub-Saharan snakes.
ADDomer©: Synthetic multiepitope display scaffold for next generation vaccines.
Research
The project comprises several technological challenges (rational design of new antigens as consensus toxins/epitope strings, design of an ADDobody library) and high-risk
research (in vitro selection of new binders from a novel protein scaffold).
Mass
spectrometry
and
bioinformatics
to analyse venoms
In vitro
evolution
and
characterization
of
ADDobody binders
Examination of neutralizing ability of selected ADDobodies
and gigabodies
Scalable bioprocess
for
gigabody production
bullets
Latest News
ADDovenom to exhibit research at Somerscience festival
Members of the ADDovenom team at University of Bristol will be taking part in the Science Fair at Somerscience, a new science, technology, engineering and maths (STEM) family festival taking place across
LSTM’s Professor Nick Casewell interviewed by BBC Radio Merseyside
As part of their coverage celebrating 125 years of the Liverpool School of Tropical Medicine, BBC Radio Merseyside’s Tony Snell interviewed Professor Nick Casewell, Head of Centre for Snakebite Research
JOB VACANCY: Research Associate, University of Bristol
This is an exciting opportunity for an enthusiastic biochemist with experience with molecular biology, protein biochemistry, and ideally antibody libraries (or similar) and display techniques to join the ADDovenom team,
Johara Stringari wins ‘best presentation’ award at SFET conference
ADDovenom researcher Johara Stringari (University of Bristol) won the ‘Best Oral Communication Award’ for her presentation at the 28th Meeting on Toxinology of the French Society of Toxinology (SFET) in
Submissions open for ‘Toxins’ Special Issue
Dr Stefanie Menzies and Prof Nicholas R. Casewell, ADDovenom researchers at Liverpool School of Tropical Medicine, have been chosen as Guest Editors of a Special Issue of the journal Toxins.
Introducing ADDovenom to postgraduates in Brazil
Johara Stringari, a Research Associate working on ADDovenom at the University of Bristol, gave a presentation on snake venom to students on the Postgraduate Program for Genetics and Biochemistry at
ADDovenom attends IST 2022
Members of the ADDovenom team have been highlighting the work of ADDovenom at the 21st World Congress of the International Society on Toxinology (IST) in Abu Dhabi (18-21 October 2022).
ADDovenom team take part in research showcase in Bristol
Members of the EU-funded ADDovenom team have been talking to the public about their work as part of the FUTURES festival, a celebration of research and innovation, held on Brunel’s
ADDovenom team gather in Marseille for annual meeting
Researchers working on the ADDovenom project met for their annual conference in Marseille, France (12-13 September), to give updates on progress made since the inaugural meeting in Bristol in 2021. The first
Experts
Christiane Berger-Schaffitzel
University of Bristol
~Project Coordinator~
Imre Berger
University of Bristol
Loïc Quinton
University of Liège
Renaud Vincentelli
Aix-Marseille University
Nicholas Casewell
Liverpool School of
Tropical Medicine
Robert Harrison
Liverpool School of
Tropical Medicine
Paula Alves
iBET
Antonio Roldão
iBET
