ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordabillity
About ADDovenom
Snakebites can be life-threatening when venom toxins are injected and enter the bloodstream. In areas where immediate access to specialised medical care is limited, bites by venomous snakes cause many thousands of deaths each year. The EU-funded ADDovenom Project will use an innovative platform enabling generation of new snakebite treatment, based on a new disruptive protein-based nanoscaffold called ADDomer© – a megadalton- sized, thermostable synthetic virus-like particle with 60 high-affinity binding sites to neutralise and eliminate venom toxins from the bloodstream. ADDovenom combines pioneering proteomics, transcriptomics and bioinformatics focusing on snake toxins provoking the most challenging syndromes like haemorrhage and paralysis. The aim is to develop first-in-class neutralising superbinders for snakebite therapy of unprecedented efficacy against the most prevalent Sub-Saharan snakes.
ADDomer©: Synthetic multiepitope display scaffold for next generation vaccines.
Research
The project comprises several technological challenges (rational design of new antigens as consensus toxins/epitope strings, design of an ADDobody library) and high-risk
research (in vitro selection of new binders from a novel protein scaffold).
Mass
spectrometry
and
bioinformatics
to analyse venoms
In vitro
evolution
and
characterization
of
ADDobody binders
Examination of neutralizing ability of selected ADDobodies
and gigabodies
Scalable bioprocess
for
gigabody production
bullets
Latest News
First ADDovenom annual meeting kicks off in Bristol
About the meeting (27 – 28th September 2021) : The ADDovenom partners gathered at the Harbour Hotel in Bristol for their first ever face-to-face meeting
Research Associate Positions in Professor Berger-Schaffitzel lab
The role: We are seeking a post-doctoral research associate to perform laboratory-based snakebite envenoming (SBE) research in the Berger-Schaffitzel lab at the University of Bristol.
Next-generation sequencing for venomics: application of Multi-Enzymatic Limited Digestion for inventorying the snake venom arsenal
Fernanda Gobbi Amorim’s abstract submission for Venoms and Toxins 2021: The 8th International Toxinology Meeting (25 – 27 August 2021). Fernanda Gobbi Amorim (1), Damien
27th Meeting of the French Society of Toxinology to be organised by Loïc Quinton
The French Society of Toxinology (SFET) is preparing for its 27th Meeting on Toxinology, entitled “Toxins: Mr Hyde or Dr Jekyll?”, on Thursday 9th and
IMI-EU funding to accelerate Advanced Therapy Medicinal Products
iBET participates in ARDAT – Accelerating Research and Innovation for Advanced Therapies – a project which aims to standardize and accelerate the development of Advanced Therapy Medicinal
Paula Alves elected for US National Academy of Engineering
ADDovenom project partner, Paula Alves (CEO of iBET – Instituto de Biologia Experimental e Tecnológica) has been elected foreign member of the National Academy of Engineering, one of
La Provence, the most read newspaper in the south of France, writes about our ADDovenom research
Loïc Quinton secures F.R.S – FNRS funding for new ‘Venoms4Liège’ project
Loïc Quinton (University of Liège) has obtained a new project, funded by the F.R.S – FNRS funding body. The 4-year funded project, which started on
ADDovenom: an innovative treatment to reduce deaths due to snake bites
A new European project, led by the University of Bristol and involving the Mass Spectrometry Laboratory (MolSys Research Unit / Faculty of Sciences) of the ULiège, will develop a
LSTM virtual seminar: Professor Rob Harrison on ‘LSTM’s research activity and impacts on tropical snakebite’
The former head of LSTM’s Head of Centre for Snakebite Research & Interventions (CSRI), Professor Rob Harrison, on behalf of Professors David Theakston, David Lalloo and Nick Casewell will
New type of antivenom to reduce 100,000 fatalities each year from venomous snake bites being developed by Bristol scientists
A new approach of treating life-threatening snake bites responsible for around 100,000 deaths globally each year is being pioneered by an international research consortium led
First ADDovenom annual meeting kicks off in Bristol
About the meeting (27 - 28th September 2021) : The ADDovenom partners gathered at the
Research Associate Positions in Professor Berger-Schaffitzel lab
The role:We are seeking a post-doctoral research associate to perform laboratory-based snakebite envenoming (SBE) research
Next-generation sequencing for venomics: application of Multi-Enzymatic Limited Digestion for inventorying the snake venom arsenal
Fernanda Gobbi Amorim's abstract submission for Venoms and Toxins 2021: The 8th International Toxinology Meeting
27th Meeting of the French Society of Toxinology to be organised by Loïc Quinton
The French Society of Toxinology (SFET) is preparing for its 27th Meeting on Toxinology, entitled
IMI-EU funding to accelerate Advanced Therapy Medicinal Products
iBET participates in ARDAT – Accelerating Research and Innovation for Advanced Therapies - a project which aims
Paula Alves elected for US National Academy of Engineering
ADDovenom project partner, Paula Alves (CEO of iBET - Instituto de Biologia Experimental e Tecnológica) has been
Latest Tweets
Experts
Christiane Berger-Schaffitzel
University of Bristol
~Project Coordinator~
Imre Berger
University of Bristol
Loïc Quinton
University of Liège
Renaud Vincentelli
Aix-Marseille University
Robert Harrison
Liverpool School of
Tropical Medicine
Nicholas Casewell
Liverpool School of
Tropical Medicine
Paula Alves
iBET
Antonio Roldão
iBET
