ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordabillity
About ADDovenom
Snakebites can be life-threatening when venom toxins are injected and enter the bloodstream. In areas where immediate access to specialised medical care is limited, bites by venomous snakes cause many thousands of deaths each year.
The EU-funded ADDovenom Project will use an innovative platform enabling generation of new snakebite treatment, based on a new disruptive protein-based nanoscaffold called ADDomer© – a megadalton- sized, thermostable synthetic virus-like particle with 60 high-affinity binding sites to neutralise and eliminate venom toxins from the bloodstream.
ADDovenom combines pioneering proteomics, transcriptomics and bioinformatics focusing on snake toxins provoking the most challenging syndromes like haemorrhage and paralysis. The aim is to develop first-in-class neutralising superbinders for snakebite therapy of unprecedented efficacy against the most prevalent Sub-Saharan snakes.
ADDomer©: Synthetic multiepitope display scaffold for next generation vaccines.
Research
The project comprises several technological challenges (rational design of new antigens as consensus toxins/epitope strings, design of an ADDobody library) and high-risk
research (in vitro selection of new binders from a novel protein scaffold).
Mass
spectrometry
and
bioinformatics
to analyse venoms
In vitro
evolution
and
characterization
of
ADDobody binders
Examination of neutralizing ability of selected ADDobodies
and gigabodies
Scalable bioprocess
for
gigabody production
bullets
Latest News
Research investigating use of Multi-Enzymatic Limited Digestion for venomics published
Members of the ADDovenom consortium at University of Liège and Liverpool School of Tropical Medicine have co-authored an article, published by Toxins on 25 May 2023, which is based on
Somerscience Festival attendees learn about ADDovenom
Members of the ADDovenom team from the University of Bristol participated in Somerscience, a new, family-friendly, science, technology, engineering, and maths (STEM) festival that took place in the Somerset towns of Castle
ADDovenom Spring Meeting 2023
ADDovenom researchers took part in their annual virtual spring meeting on 20 April 2023. The project team meet every six months (either in person or virtually) to share updates on
Researcher Spotlight: Renaud Vincentelli
For our Researcher Spotlight features, we interview members of the ADDovenom research team, to find out about their interests, their contributions to the project, and their hopes for the future
ADDovenom researcher interviewed by BBC, Telegraph
This month, LSTM’s Prof Nick Casewell has been interviewed by both the BBC’s Health Check radio show, and the Daily Telegraph newspaper. A reporter for the BBC World Service show visited the Centre
JOB VACANCY: Research Associate, University of Bristol
** Applications are now closed ** This is an exciting opportunity for an enthusiastic biochemist with experience with molecular biology, protein biochemistry, and ideally antibody libraries (or similar) and display
ADDovenom to exhibit research at Somerscience festival
Members of the ADDovenom team at University of Bristol will be taking part in the Science Fair at Somerscience, a new science, technology, engineering and maths (STEM) family festival taking place across
LSTM’s Professor Nick Casewell interviewed by BBC Radio Merseyside
As part of their coverage celebrating 125 years of the Liverpool School of Tropical Medicine, BBC Radio Merseyside’s Tony Snell interviewed Professor Nick Casewell, Head of Centre for Snakebite Research
Johara Stringari wins ‘best presentation’ award at SFET conference
ADDovenom researcher Johara Stringari (University of Bristol) won the ‘Best Oral Communication Award’ for her presentation at the 28th Meeting on Toxinology of the French Society of Toxinology (SFET) in
Experts
Christiane Berger-Schaffitzel
University of Bristol
~Project Coordinator~
Imre Berger
University of Bristol
Loïc Quinton
University of Liège
Renaud Vincentelli
Aix-Marseille University
Nicholas Casewell
Liverpool School of
Tropical Medicine
Robert Harrison
Liverpool School of
Tropical Medicine
Paula Alves
iBET
Antonio Roldão
iBET
