ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordabillity
About ADDovenom
Snakebites can be life-threatening when venom toxins are injected and enter the bloodstream. In areas where immediate access to specialised medical care is limited, bites by venomous snakes cause many thousands of deaths each year.
The EU-funded ADDovenom Project will use an innovative platform enabling generation of new snakebite treatment, based on a new disruptive protein-based nanoscaffold called ADDomer© – a megadalton- sized, thermostable synthetic virus-like particle with 60 high-affinity binding sites to neutralise and eliminate venom toxins from the bloodstream.
ADDovenom combines pioneering proteomics, transcriptomics and bioinformatics focusing on snake toxins provoking the most challenging syndromes like haemorrhage and paralysis. The aim is to develop first-in-class neutralising superbinders for snakebite therapy of unprecedented efficacy against the most prevalent Sub-Saharan snakes.

ADDomer©: Synthetic multiepitope display scaffold for next generation vaccines.
Research
The project comprises several technological challenges (rational design of new antigens as consensus toxins/epitope strings, design of an ADDobody library) and high-risk
research (in vitro selection of new binders from a novel protein scaffold).
Mass
spectrometry
and
bioinformatics
to analyse venoms
In vitro
evolution
and
characterization
of
ADDobody binders
Examination of neutralizing ability of selected ADDobodies
and gigabodies
Scalable bioprocess
for
gigabody production
bullets
Latest News
JOB VACANCY: Research Assistant, LSTM
Would you like to join our international, multi-disciplinary team of researchers who are dedicated to developing novel protein-based snakebite treatments? The Centre for Snakebite Research and Interventions (CSRI) at the
EVENT: Venoms – Drugs and Antidotes
ADDovenom researcher Nick Casewell (Liverpool School of Tropical Medicine) will be one of the speakers for the Academic Drug Discovery Consortium‘s latest ‘Things You Need To Know’ webinar which takes
This Podcast Will Kill You explores snake venom
This Podcast Will Kill You (TPWKY), a podcast about infectious diseases, has interviewed ADDovenom team member Nick Casewell for a special episode about snake venom evolution. The hour-long conversation with
ADDovenom researchers feature in National Geographic
ADDovenom Project Co-ordinator Christiane Berger-Schaffitzel (University of Bristol) and ADDovenom researcher Nick Casewell (Liverpool School of Tropical Medicine) have been interviewed for an article about the potential for a universal
Researcher Spotlight: Fernanda Amorim
For our Researcher Spotlight features, we interview members of the ADDovenom research team, to find out about their interests, their contributions to the project, and their hopes for the future
Snakebite antivenoms step into the future
ADDovenom researchers Nick Casewell and Robert Harrison, from Liverpool School of Tropical Medicine, have been interviewed for an article published by the Drug Discovery Network. Written by Stephanie DeMarco and published
Researcher Spotlight: Johara Stringari
For our Researcher Spotlight features, we interview members of the ADDovenom research team, to find out about their interests, their contributions to the project, and their hopes for the future
Presenting ADDovenom (and seeing rattlesnakes) in California
Stefanie Menzies and Becky Edge, ADDovenom postdoctoral researchers from the Liverpool School of Tropical Medicine, gave poster presentations at the 2022 Gordon Research Conference on Antibody Biology and Engineering, which
Researcher Spotlight: Raquel Garcia
For our Researcher Spotlight features, we interview members of the ADDovenom research team, to find out about their interests, their contributions to the project, and their hopes for the future
JOB VACANCY: Research Assistant, LSTM
Would you like to join our international, multi-disciplinary team of researchers who are dedicated to
EVENT: Venoms – Drugs and Antidotes
ADDovenom researcher Nick Casewell (Liverpool School of Tropical Medicine) will be one of the speakers
This Podcast Will Kill You explores snake venom
This Podcast Will Kill You (TPWKY), a podcast about infectious diseases, has interviewed ADDovenom team
ADDovenom researchers feature in National Geographic
ADDovenom Project Co-ordinator Christiane Berger-Schaffitzel (University of Bristol) and ADDovenom researcher Nick Casewell (Liverpool School
Researcher Spotlight: Fernanda Amorim
For our Researcher Spotlight features, we interview members of the ADDovenom research team, to find
Snakebite antivenoms step into the future
ADDovenom researchers Nick Casewell and Robert Harrison, from Liverpool School of Tropical Medicine, have been
Experts

Christiane Berger-Schaffitzel
University of Bristol
~Project Coordinator~

Imre Berger
University of Bristol

Loïc Quinton
University of Liège

Renaud Vincentelli
Aix-Marseille University

Nicholas Casewell
Liverpool School of
Tropical Medicine

Robert Harrison
Liverpool School of
Tropical Medicine

Paula Alves
iBET

Antonio Roldão
iBET